Fri Sep 23 10:27:41 2011
Approvals Received: |
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Approvals Pending: | College/Dean > Catalog > CCE Catalog | |
Effective Status: | Active | |
Effective Term: | 1119 - Fall 2011 | |
Course: | BMEN 5412 | |
Institution: Campus: |
UMNTC - Twin Cities UMNTC - Twin Cities |
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Career: | UGRD | |
College: | TIOT - College of Science and Engineering | |
Department: | 11143 - Biomedical Engineerng, Dept of | |
General | ||
Course Title Short: | Neuromodulation | |
Course Title Long: | Neuromodulation | |
Max-Min Credits for Course: |
3.0 to 3.0 credit(s) | |
Catalog Description: |
Fundamentals of bioengineering approaches to modulate the nervous system including bioelectricity, biomagnetism, and optogenetics. Topics include computational modeling, design, and physiological mechanisms of neuromodulation technologies. Clinical exposure to managing neurological disorders with neuromodulation technology will be emphasized. | |
Print in Catalog?: | Yes | |
CCE Catalog Description: |
Fundamentals of bioengineering approaches to modulate the nervous system including bioelectricity, biomagnetism, and optogenetics. Topics include design of computational models of neuromodulation, fabrication of neural interface devices, and development of technologies to evaluate the physiological effects of neuromodulation. Clinical exposure to managing neurological diseases and disorders with neuromodulation technology will be emphasized. | |
Grading Basis: | A-F only | |
Topics Course: | No | |
Honors Course: | No | |
Delivery Mode(s): | Classroom | |
Instructor Contact Hours: |
3.0 hours per week | |
Years most frequently offered: |
Every academic year | |
Term(s) most frequently offered: |
Spring | |
Component 1: |
LEC (no final exam) |
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Auto-Enroll Course: |
No | |
Graded Component: |
LEC | |
Academic Progress Units: |
Not allowed to bypass limits. 3.0 credit(s) |
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Financial Aid Progress Units: |
Not allowed to bypass limits. 3.0 credit(s) |
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Repetition of Course: |
Repetition not allowed. | |
Course Prerequisites for Catalog: |
5411 or instructor approval. | |
Course Equivalency: |
No course equivalencies | |
Consent Requirement: |
No required consent | |
Enforced Prerequisites: (course-based or non-course-based) |
003326 - BMEn 5411 | |
Editor Comments: | <no text provided> | |
Proposal Changes: | <no text provided> | |
History Information: | <no text provided> | |
Faculty Sponsor Name: |
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Faculty Sponsor E-mail Address: |
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Student Learning Outcomes | ||
Student Learning Outcomes: |
* Student in the course:
- Can identify, define, and solve problems
Please explain briefly how this outcome will be addressed in the course. Give brief examples of class work related to the outcome. Students learn about the physiological basis for neurological disorders and how to develop technologies to treat neurological disorders. How will you assess the students' learning related to this outcome? Give brief examples of how class work related to the outcome will be evaluated. Through weekly problem sets, students are presented with clinical problems and are evaluated on the technical rigor of the bioengineering approaches they use to solve these clinical problems, which often have no one right answer. - Can locate and critically evaluate information Please explain briefly how this outcome will be addressed in the course. Give brief examples of class work related to the outcome. Students learn to locate and critically analyze journal articles on current topics in neuromodulation. How will you assess the students' learning related to this outcome? Give brief examples of how class work related to the outcome will be evaluated. Through weekly problem sets, students are evaluated on the depth of their understanding of the material and their ability to articulate limitations to experimental studies in the literature. - Have mastered a body of knowledge and a mode of inquiry Please explain briefly how this outcome will be addressed in the course. Give brief examples of class work related to the outcome. Students complete an extensive final neuromodulation design project requiring both written and oral presentation. How will you assess the students' learning related to this outcome? Give brief examples of how class work related to the outcome will be evaluated. Students are evaluated on the effectiveness and appropriateness of their research and choice of technology. - Understand the role of creativity, innovation, discovery, and expression across disciplines Please explain briefly how this outcome will be addressed in the course. Give brief examples of class work related to the outcome. Students are involved in a series of interactive experimental, computational, and representational argument practicums in which they must synthesize material presented in class. How will you assess the students' learning related to this outcome? Give brief examples of how class work related to the outcome will be evaluated. Students are evaluated on the success, innovativeness, and depth of their inter-disciplinary solutions to the interactive practicums. |
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Liberal Education | ||
Requirement this course fulfills: |
None | |
Other requirement this course fulfills: |
None | |
Criteria for Core Courses: |
Describe how the course meets the specific bullet points for the proposed core
requirement. Give concrete and detailed examples for the course syllabus, detailed
outline, laboratory material, student projects, or other instructional materials or method.
Core courses must meet the following requirements:
<no text provided> |
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Criteria for Theme Courses: |
Describe how the course meets the specific bullet points for the proposed theme
requirement. Give concrete and detailed examples for the course syllabus, detailed outline,
laboratory material, student projects, or other instructional materials or methods. Theme courses have the common goal of cultivating in students a number of habits of mind:
<no text provided> |
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Writing Intensive | ||
Propose this course as Writing Intensive curriculum: |
No | |
Question 1 (see CWB Requirement 1): |
How do writing assignments and writing instruction further the learning objectives
of this course and how is writing integrated into the course? Note that the syllabus must
reflect the critical role that writing plays in the course. <no text provided> |
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Question 2 (see CWB Requirement 2): |
What types of writing (e.g., research papers, problem sets, presentations,
technical documents, lab reports, essays, journaling etc.) will be assigned? Explain how these
assignments meet the requirement that writing be a significant part of the course work, including
details about multi-authored assignments, if any. Include the required length for each writing
assignment and demonstrate how the minimum word count (or its equivalent) for finished writing will
be met. <no text provided> |
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Question 3 (see CWB Requirement 3): |
How will students' final course grade depend on their writing performance?
What percentage of the course grade will depend on the quality and level of the student's writing
compared to the percentage of the grade that depends on the course content? Note that this information
must also be on the syllabus. <no text provided> |
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Question 4 (see CWB Requirement 4): |
Indicate which assignment(s) students will be required to revise and resubmit after
feedback from the instructor. Indicate who will be providing the feedback. Include an example of the
assignment instructions you are likely to use for this assignment or assignments. <no text provided> |
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Question 5 (see CWB Requirement 5): |
What types of writing instruction will be experienced by students? How much class
time will be devoted to explicit writing instruction and at what points in the semester? What types of
writing support and resources will be provided to students? <no text provided> |
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Question 6 (see CWB Requirement 6): |
If teaching assistants will participate in writing assessment and writing instruction,
explain how will they be trained (e.g. in how to review, grade and respond to student writing) and how will
they be supervised. If the course is taught in multiple sections with multiple faculty (e.g. a capstone
directed studies course), explain how every faculty mentor will ensure that their students will receive
a writing intensive experience. <no text provided> |
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Readme link.
Course Syllabus requirement section begins below
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Course Syllabus | ||
Course Syllabus: |
For new courses and courses in which changes in content and/or description and/or credits
are proposed, please provide a syllabus that includes the following information: course goals
and description; format;structure of the course (proposed number of instructor contact
hours per week, student workload effort per week, etc.); topics to be covered; scope and
nature of assigned readings (text, authors, frequency, amount per week); required course
assignments; nature of any student projects; and how students will be
evaluated. The University "Syllabi Policy" can be
found here
The University policy on credits is found under Section 4A of "Standards for Semester Conversion" found here. Course syllabus information will be retained in this system until new syllabus information is entered with the next major course modification. This course syllabus information may not correspond to the course as offered in a particular semester. (Please limit text to about 12 pages. Text copied and pasted from other sources will not retain formatting and special characters might not copy properly.) This course was originally offered as a Special Topics course (BMEn 5910). A pdf of that syllabus is available upon request from Rachel at bmengp@umn.edu. See below for an unformatted version. Course Information Course Instructor: Professor Matt Johnson E-mail: john5101@umn.edu (please include BMEn 5910 in the subject) Office: 6-134 NHH Office Hours: TBD Course Meetings: T/Th 8: 15-9:30 am Course Website: Moodle Course Description: Fundamentals of bioengineering approaches to modulate the nervous system including bioelectricity, biomagnetism, and optogenetics. Topics include design of computational models of neuromodulation, fabrication of neural interface devices, and development of technologies to evaluate the physiological effects of neuromodulation. Clinical exposure to managing neurological diseases and disorders with neuromodulation technology will be emphasized. Course Text: Neuroanatomy through Clinical Cases by Hal Blumenfeld; Reading supplements will be provided to you in class. Course Prerequisites: BMEn 5411, or permission from the instructor. Course Format: This is a lecture-based course consisting of two 75-minute lecture sessions per week. We will have periodic in-class demonstrations to reinforce concepts and homework sets that use real data from humans and animal models. Students will have opportunities through this course to shadow clinicians in the implantation and programming of neuromodulation devices. Grading Policy: Course assessment will be based on weekly homework assignments (30%), a midterm (30%), a final exam (30%), and classroom participation / final report (10%). Grading will be based on 100-90%=A, 89-80%=B, 79-70%=C. The threshold for grades may be lowered depending on overall class performance. Homework (30%) -- Weekly problem sets will focus on your ability to integrate concepts across several engineering, physiology, and clinical disciplines. Assignments will be due one week after they are distributed in class. We will use MATLAB in the homework, so familiarity with this software package will be useful. Midterm (30%) -- The midterm will allow you to demonstrate your understanding of neural implants and the fundamentals bioelectricity, biomagnetism, and optogenetic stimulation. Final Exam (30%) The final exam will provide you with a chance to apply the principles you have learned through the semester and extend those concepts to other neurological disorders. Classroom Participation / Final Project (10%) Undergraduate students will be evaluated on participation in class whereas graduate students will write a critical review paper comparing the effectiveness and future potential of two different neuromodulation techniques for a specific neurological disorder. E-mail Policy: I will try to respond to your e-mails as quickly as possible. For questions on the homework, please use the discussion forum on the website so that everyone in the course can benefit. Class Policies: Students may work in groups for the homework, but the expectation is for each student to hand in his or her own work and abide by the Student Conduct Code. Re-grades on homework and the midterm need to be submitted to me within one week of when I hand them back to you. Should you need to reschedule the midterm, please give me at least two weeks notice. Any other questions or concerns by all means, feel free to stop by during office hours or e-mail me at john5101@umn.edu. I look forward to a great semester! Schedule of Lectures and Assignments (tentative) Date Lect Theme Topic Reading Homework Distributed 18-Jan 1 Introduction Course Introduction Course syllabus Macroscopic overview of the nervous system Technology to modulate the nervous system 20-Jan 2 Introduction Clinical Neuroanatomy Clinical cases: peripheral nervous system Clinical cases: central nervous system Blumenfeld Ch 2 HW 1 25-Jan 3 Introduction Clinical Neuroradiology Clinical cases: computerized tomography (CT) Clinical cases: magnetic resonance imaging (MRI) Clinical cases: angiography Blumenfeld Ch 4 27-Jan 4 Introduction The Neurologic Exam Guest lecture Dr. Jerrold Vitek (Neurology) In class demonstration Blumenfeld Ch 3 HW 2 1-Feb 5 Meninges and Vasculature Management Cranium, Vertebrate, and Meninges Clinical cases: intracranial implants, herniation Design of intracranial pressure technologies Design of cranial and dural repair technologies Blumenfeld Ch 5 3-Feb 6 Meninges and Vasculature Management Subdural Malformations Clinical cases: tumors Design of ablation technologies: gamma-knife, cooling, radiofrequency, electrolytic lesioning HW 3 8-Feb 7 Meninges and Vasculature Management Blood-Brain Barrier Clinical cases: tumors, edema Design of intracranial drug-delivery technologies Design of technologies to bypass the BBB 10-Feb 8 Meninges and Vasculature Management Cerebral Vasculature Clinical cases: stroke and aneurysms Design of diagnostic tools Design of intravascular delivery approaches Blumenfeld Ch 10 HW 4 15-Feb 9 Neuromodulation Approaches Treatment for Stroke Guest lecture Dr. Kenneth Baker (Neurology) Design of epidural and subdural stimulation systems Design of stimulation to induce neural plasticity 17-Feb 10 Neuromodulation Approaches Non-Invasive Neuromodulation I Principles of transcranial magnetic stimulation (TMS) Modeling electromagnetic fields in neural tissue Effects of TMS frequency on neurophysiology Liepert 2000 HW 5 22-Feb 11 Neuromodulation Approaches Non-Invasive Neuromodulation II Principles of transcranial direct current stimulation Modeling electric fields in the neural tissue Effects of constant current versus pulse trains Hummel 2005 24-Feb 12 Neuromodulation Approaches Modeling Electrical Fields in Neural Tissue I Homogeneous finite element models Current versus voltage-controlled stimulation Design of multi-polar stimulation systems HW 6 1-Mar 13 Neuromodulation Approaches Modeling Electrical Fields in Neural Tissue II Heterogeneous finite element models Diffusion tensor imaging and impedance tomography Tissue response to intracranial implants 3-Mar 14 Neuromodulation Approaches Optogenetic Neuromodulation I Principles of light-activated ion channels Strategies for delivering microbial opsin genes Optimizing expression and function Gradinaru 2010 prepare for midterm 8-Mar 15 Neuromodulation Approaches Optogenetic Neuromodulation II Design of intracranial infusion systems Neural responses to optical stimulation Optical control of behavior Zhang 2010 10-Mar 16 Midterm 15-Mar -- Spring Break 17-Mar -- 22-Mar 17 Neuromodulation Approaches Design of Electrodes I Designing multi-channel electrode geometries and configurations specifically for the anatomical target Insulation and biocompatibility issues 24-Mar 18 Neuromodulation Approaches Design of Electrodes II Microfabrication processes: photolithography, chemical vapor deposition, metal deposition, etching Polymer versus silicon substrates HW 7 29-Mar 19 Neuromodulation Approaches Design of Electrodes III Integration of drug delivery channels Integration of optrode design Optimization for biocompatibility Zhang 2009 31-Mar 20 Evaluating Neuromodulation Therapies Measuring Effects of Neuromodulation I Non-invasive functional imaging (fMRI, EEG, MEG) Designing therapies for clinical subtypes MR / device compatibility issues HW 8 29-Mar 21 Evaluating Neuromodulation Therapies Measuring Effects of Neuromodulation II Intracranial microelectrode recordings Stimulus artifact suppression techniques Signal processing algorithms for spikes and LFPs 31-Mar 22 Evaluating Neuromodulation Therapies Measuring Effects of Neuromodulation III Intracranial neurotransmitter recordings Voltammetry and amperometry Microdialysis techniques HW 9 5-Apr 23 Evaluating Neuromodulation Therapies Physiological Mechanisms of Neuromodulation Excitation or inhibition? Release of neurotransmitters Effects on synchronicity 7-Apr 24 Neuromodulation Applications Neuromodulation for Pain Pathophysiology and clinical cases Spinal cord and thalamic stimulation Multi-channel programming Blumenfeld Ch 7-9 HW 10 12-Apr 25 Neuromodulation Applications Neuromodulation for Essential Tremor Pathophysiology and clinical cases Sculpting stimulation according to brain somatotopy Designing settings to avoid paresthesia side-effects Blumenfeld Ch 16 14-Apr 26 Neuromodulation Applications Neuromodulation for Parkinsons disease Pathophysiology and clinical cases Mechanisms underlying multiple stimulation targets Possible neuroprotective effects of stimulation HW 11 19-Apr 27 Neuromodulation Applications Neuromodulation for Dystonia Pathophysiology and clinical cases Stimulation-induced neural plasticity Temporal effects of therapeutic onset/cessation 21-Apr 28 Neuromodulation Applications Neuromodulation for Epilepsy Pathophysiology and clinical cases, Dr. Abosch Identification of pathological brain regions Automated closed-loop stimulation Blumenfeld Ch 18 HW 12 26-Apr 29 Neuromodulation Applications Neuromodulation for Depression and OCD Pathophysiology and clinical cases Fiber tractography and neuromodulation Issues of power consumption and battery life 28-Apr 30 Neuromodulation Applications Neuromodulation Emerging Areas Alzheimers disease, obesity, Tourettes syndrome, Designing stimulation systems to the target anatomy Ethical issues with neuromodulation Blumenfeld Ch 17 grad project abstract due 3-May 31 Translational Neuroengineering Intellectual Property and Seed Funding Provisional patents and patents through UMN NIH SBIR/STTR grants and venture capital 5-May 32 Translational Neuroengineering FDA Process Phases of clinical trials Process for bringing a device to market grad project report due ??-May Finals Final Exam |
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Readme link.
Strategic Objectives & Consultation section begins below
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Strategic Objectives & Consultation | ||
Name of Department Chair Approver: |
<no text provided> | |
Strategic Objectives - Curricular Objectives: |
How does adding this course improve the overall curricular objectives ofthe unit? <no text provided> |
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Strategic Objectives - Core Curriculum: |
Does the unit consider this course to be part of its core curriculum? <no text provided> |
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Strategic Objectives - Consultation with Other Units: |
In order to prevent course overlap and to inform other departments of new
curriculum, circulate proposal to chairs in relevant units and follow-up with direct
consultation. Please summarize response from units consulted and include correspondence. By
consultation with other units, the information about a new course is more widely disseminated
and can have a positive impact on enrollments. The consultation can be as simple as an
email to the department chair informing them of the course and asking for any feedback
from the faculty. <no text provided> |
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