University of Minnesota
Aerospace Engineering and Mechanics
Spring 2003 Seminar Series



Mechanics of DNA Packaging: From Viruses to Chromosomes


Prof. Rob Phillips

Mechanical Engineering and Applied Physics, California Institute of Technology


Abstract

As a result of recent advances in single molecule biomechanics, it has now become possible to examine the response of individual proteins and DNA to piconewton forces. One class of intriguing problems that have been attacked using these methods are those associated with the packing of DNA in viruses. This talk will describe single molecule experiments aimed at measuring the forces exerted by molecular motors during DNA packing and will develop a simple model based upon elasticity and interaction forces between adjacent DNA segments which has proved fruitful in interpreting these experiments.

Friday, February 21, 2003
209 Akerman Hall
2:30-3:30 p.m.


Refreshments served after the seminar in 227 Akerman Hall.
Disability accomodations provided upon request.
Contact the AEM Office, 612-625-8000.