Much of what we know about clasical fluid mechanics at high Reynolds numbers originates from theories which assume the fluid motions are both isotropic and homogeneous. However, almost all real flows are both anisotropic and heterogeneous. The efficacy of the established theory results from the idea of "local isotropy". That is, at small enough scale the fluid motions are not dependent on the boundary conditions of a given problem. Considerable time and effort has been put forth in the last 50 years towards better understanding, validation, and modeling of the universal nature of the small scales of motion. In this talk, experimental data will be presented from several canonical flows that exploits the heterogeneous and anisotropic nature of flows at all length scales. Theoretical and experimental observations of the vorticity field will be used to catalyze the discussion. It will be argued that future modeling efforts, and in particular time dependent calculations such as LES, will depend on theories which explicitly account for non-universal flow features.