University of Minnesota
Aerospace Engineering and Mechanics
Winter 1999 Seminar Series



An anisotropic biphasic model for the mechanics of bioartificial tissues: applications to tissue fabrication and characterization of cell traction force


Professor Robert Tranquillo

Department of Chemical Engineering and Materials Science

University of Minnesota


Abstract


There is much interest in the concept of creating bioartificial tissues by reconstituting monomeric type I collagen into a fibrillar network, entrapping cells of interest in the process. An intrinsic property of such "tissue-equivalents" is the compaction of the collagen network due to traction exerted by the entrapped cells - a cell-induced gel syneresis. The rationale design of tissue analogs therefore requires a continuum mechanical model that accounts for the ensuing mechanical interplay: cell traction drives network deformation that induces fibril alignment, which in turn induces cell contact guidance. An anisotropic biphasic theory for tissue-equivalent mechanics is described, including the determination of the various constitutive equations (e.g. collagen network viscoelasticity and cell contact guidance), its validation in simplifying geometries, and its application to fabrication of circumferentially-aligned smooth muscle cell/collagen tubes as an analog of the medial layer of a bioartificial artery.

Friday, January 22, 1999
209 Akerman Hall
2:30-3:30 p.m.


Refreshments served after the seminar in 227 Akerman Hall.
Disability accomodations provided upon request.
Contact Kristal Belisle, Senior Secretary, 625-8000.