University of Minnesota
Aerospace Engineering and Mechanics
Winter 1999 Seminar Series
An anisotropic biphasic model for the mechanics of bioartificial
tissues: applications to tissue fabrication and characterization of cell
There is much interest in the concept of creating bioartificial tissues by
reconstituting monomeric type I collagen into a fibrillar network, entrapping
cells of interest in the process. An intrinsic property of such
"tissue-equivalents" is the compaction of the collagen network due to
traction exerted by the entrapped cells - a cell-induced gel syneresis. The
rationale design of tissue analogs therefore requires a continuum mechanical
model that accounts for the ensuing mechanical interplay: cell traction drives
network deformation that induces fibril alignment, which in turn induces cell
contact guidance. An anisotropic biphasic theory for tissue-equivalent
mechanics is described, including the determination of the various constitutive
equations (e.g. collagen network viscoelasticity and cell contact guidance),
its validation in simplifying geometries, and its application to fabrication of
circumferentially-aligned smooth muscle cell/collagen tubes as an analog of the
medial layer of a bioartificial artery.
Friday, January 22, 1999
Refreshments served after the seminar in
227 Akerman Hall.
Disability accomodations provided upon request.
Contact Kristal Belisle, Senior