Adjust Font Size:

University of Minnesota Twin Cities Campus

Course Catalog by Subject

TwoStop Home

---

Select a Subject to display
Subject:	AAS ABUS ACCT ACL ADDS ADES ADPY AECM AEM AFRO AGRO AHS AIR AKKA AMES AMIN AMST ANAT ANES ANSC ANTH APEC APS APSC APST ARAB ARCH ARGN ARTH ARTS ASCL ASL AST BA BBE BCLA BIOC BIOL BLAW BMEN BSE BTHX CAHP CAPY CDED CEGE CESP CFAN CGSC CHEM CHEN CHIC CHMB CHN CHPH CI CIVE CL CLA CMB CMBA CMGT CMPE CNRC COMM CONS COP CPMS CPSY CSCI CSCL CSE CSOM CSPH CVM DAKO DBLN DDS DENT DERM DES DH DNCE DSCI DSSC DT DTCH EAS ECDR ECON ECP EDHD EDUC EE EEB EMMD EMS ENDO ENGL ENGW ENT ENTR EPSY ESCI ESL ESPM FDSY FIN FINA FLOR FM FMCH FNRM FOST FREN FRIT FSCN FSOS FW GCC GCD GDBA GDES GEND GEOG GER GERI GERO GHSR GIS GLBT GLOS GME GRAD GRD GRK GSD GWSS HCOL HEBR HECU HINF HIST HMED HMNG HNDI HNUR HORT HRIR HSCI HSEM HSEX HSG HSM HSPH HUMF IBH IBUS ICP IDES IDSC IE IFSL INAR INET INMD INS IREL ITAL JOUR JPN JWST KIN KNYA KOR LA LAAS LAMP LANG LAS LASK LAT LAW LEAD LGTT LING LM LNDN MABA MADR MATH MATS MBA MBS MBT MCDG MCOM MDI MDP MDS ME MED MEDC MEST MGMT MICA MICB MICE MIL MILI MIMB MIMS MKTG MLK MLSP MM MNMD MONT MORT MOT MPHY MRCO MSBA MSF MSID MSMK MST MTHE MUED MULT MUS MUSA NAV NEUR NOR NR NSC NSCI NSU NURS NUTR OBIO OBST OCS OJIB OLPD OPH ORSU OSUR OT OTHO OTOL OUE PA PATH PDEN PDES PE PED PERO PERS PHAR PHCL PHIL PHM PHRM PHSL PHYS PLPA PLSC PMB PMED POL PORT POUL PREV PROS PSY PT PUBH RAD RELS RM ROB ROME RSC RUSS SACP SAGR SAPH SCAN SCB SCIC SCLY SCMC SCO SDNY SENG SFS SLAV SLHS SMGT SMLI SNGL SOC SOIL SPAN SPPT SSM SST ST STAT SURG SUST SW SWAH SWED TH THAI TLDO TMDP TRAD TXCL UC UGRD URBS URDU UROL VBS VCS VIRO VMBA VMED VPM VTMD WRIT WRS YOST			Show Scheduled Topics for Topics Courses

---

Medicinal Chemistry (MEDC) Courses

Academic Unit: Medicinal Chemistry Rsch

MEDC 5185 - Principles of Biomolecular Simulation

(3 cr; Prereq-Chem 3502 or instr consent; Student Option; offered Periodic Fall)

Molecular simulation for students in medicinal chemistry, pharmaceutics, biochemistry, and chemical physics

MEDC 5200 - The New Drug Development Process

(1 cr; Student Option; offered Periodic Fall & Spring)

Equivalent courses: was PHM 5200 until 02-SEP-08

New drug development process in the U.S. pharmaceutical industry.

MEDC 5245 - Introduction to Drug Design

(3 cr; Prereq-Chem; A-F or Audit; offered Every Fall)

Equivalent courses: CHEM 5245 (inactive), PHAR 6245 (inactive, starting 31-JAN-00)

Concepts that govern design/discovery of drugs. Physical, bioorganic, medicinal chemical principles applied to explain rational design, mechanism of action drugs.

MEDC 5485 - Drug Metabolism and Pharmacokinetics

(3 cr; A-F or Audit; offered Periodic Fall & Spring)

Drug Metabolism and Pharmacokinetics is a stand-alone elective that is intended for Medicinal Chemistry graduate students or other students interested in the drug development process. Absorption and pharmacokinetic principles will be supplemented with problem sets. The primary method of instruction is lecture-based with the use of textbook readings and review articles as support for class notes and discussions. A total of 2 non-cumulative exams will be given during the semester. Prerequisites: Organic Chemistry, Med Chem 8001 (may be waived for students from other programs). This course adheres to the items listed in the College of Pharmacy Central Syllabus: https://docs.google.com/a/umn.edu/document/d/1artQ5e1rbzxe8lEtWo7BE8k8snZAEgMMz_QcW8yJ-II/edit?pli=1

MEDC 5494 - Advanced Methods in Quantitative Drug Analysis

(2 cr; A-F or Audit; offered Periodic Fall & Spring)

Quantitative methods (HPLC, GC, TLC, immunoassays) for analysis of drugs/metabolites in biological fluids. Advanced techniques such as capillary electrophoresis, supercritical fluid chromatography, GC-MS, LC-MS, tandem mass spectrometry. Chromatographic theory/statistical approaches to method validation.

MEDC 5495 - Vistas in Medicinal Chemistry Research

(1 cr; S-N or Audit; offered Every Fall)

Selected topics of contemporary interest in medicinal chemistry

MEDC 8001 - General Principles of Medicinal Chemistry

(3 cr; Prereq-Med chem grad student or instr consent; A-F or Audit; offered Every Fall)

Fundamental principles of molecular recognition, physiochemical properties of drugs, drug metabolism and disposition, interaction of molecules with DNA/RNA.

MEDC 8002 - General Principles of Medicinal Chemistry

(3 cr; Prereq-Med chem grad student or instr consent; A-F or Audit; offered Every Spring)

Fundamental principles of molecular recognition, physicochemical properties of drugs, drug metabolism and disposition, interaction of molecules with DNA/RNA.

MEDC 8050 - Physical and Mechanistic Organic Chemistry

(2 cr; Prereq-First-year Medicinal Chemistry grad students or by permission.; A-F only; offered Every Fall)

Didactic instruction in foundational principles of physical and mechanistic organic chemistry. Recitation component in which students actively solve organic chemistry reaction mechanisms and related problems in organic and medicinal chemistry during course meeting times with faculty guidance.

MEDC 8070 - The Chemistry and Biology of Infectious Diseases

(3 cr; A-F only; offered Periodic Fall & Spring)

The objectives of this course are to provide a comprehensive overview of antimicrobial agents used in infectious diseases with an emphasis on the underlying foundational principles in chemistry and biology. Antibiotic, antifungal, and antiprotozoal agents will be covered. For each antimicrobial agent, the history, discovery, synthesis, structure-activity relationships, spectrum of activity, clinical uses, mechanism(s) of action, resistance, drug disposition properties, and adverse reactions will be discussed in great detail.

MEDC 8100 - Medicinal Chemistry Seminar

(1 cr; Prereq-Grad major or instr consent; A-F only; offered Every Fall & Spring; may be repeated for 6 credits; may be repeated 6 times)

Current topics.

MEDC 8333 - FTE: Master's

(1 cr; Prereq-Master's student, adviser and DGS consent; No Grade Associated; offered Every Fall, Spring & Summer; 6 academic progress units; 6 financial aid progress units)

(No description)

MEDC 8396 - Practical Training in Medicinal Chemistry (Topics course)

(1 cr; S-N only; offered Every Fall, Spring & Summer; may be repeated for 3 credits; may be repeated 3 times)

Industrial or other external work experience involving medicinal chemistry and/or related disciplines. Reviewed/approved by faculty advisor and director of graduate studies. Grade based on report prepared by the student summarizing the completed work experience.

MEDC 8401 - Chemistry of Counterterrorism: Chemical, Biological, Radiological, Nuclear & High Explosive Threats

(2 cr; A-F only; offered Spring Odd Year)

Students will acquire fundamental knowledge of the mechanisms of action, risks, and potential effects of the major CBRNE (chemical, biological, radiological, nuclear, and high explosive) agents that pose a threat in terrorist attacks. Students will also develop familiarity with current countermeasures (pre- and post-exposure) and relevant medical treatments, focusing on effectiveness, limitations, unmet needs, challenges, and roadblocks to countermeasure development. Detection, protection, and decontamination techniques will also be discussed. This course is designed for scientists and engineers: graduate students in Medicinal Chemistry, Chemistry, Biochemistry, Chemical Engineering, Biomedical Engineering, or Physics. Advanced undergraduates in the above programs, and professional students in PharmD, MD, MD/PhD, DVM, or MPH programs, who meet all required prerequisites, may enroll with the course director?s permission. Note that the emphasis of this course is on the chemistry, biology, and physics of CBRNE agents and their countermeasures, not policy, policymaking, or sociocultural issues (although these may come up for discussion).

MEDC 8405 - Translational Experience in Drug Discovery and Development (TED3)

(3 cr; A-F only; offered Spring Even Year)

To provide an overview and understanding of the process of drug discovery and exposure to the issues and challenges of drug discovery.

MEDC 8413 - Chemistry of Nucleic Acids

(4 cr; Prereq-[Medicinal chem or chem or biochem] grad student; A-F only; offered Spring Even Year)

Chemical aspects of nucleic acid structure and function, synthesis, and functional variants.

MEDC 8420 - Natural Products Chemistry

(3 cr; Prereq-[CHEM 8321, biochemistry] or equiv or course director approval; A-F only; offered Spring Odd Year)

Biosynthesis of natural products with an emphasis on how these biochemical principles can be used in drug discovery and design through metabolic engineering and combinatorial biosynthesis. Natural product isolation, structure determination, target identification, and the role of synthetic organic chemistry.

MEDC 8435 - BioAssay & Data Analysis

(1 cr; Prereq-MEDC 8001 or instructor permission.; A-F or Audit; offered Spring Even Year)

Emphasis is an intro to bioassay & rodent experimental design approaches, data analysis & basic statistical analysis of corresponding data. Concepts of what instrumentation resources are available within the Department of Medicinal Chemistry & the Institute for Therapeutics Discovery & Development (ITDD), what the corresponding bioassays that can be measured on those resources, considerations & criteria for the development of a new bioassay, how to design basic rodent (mouse & rat) animal experiments including power-analysis (how to predict the number of animals needed for the experiment), as well as data analysis [mean, standard error of the mean (SEM), standard deviation of the mean (SD)] & statistical analysis [student t-test, one-way Anova, two-way Anova, & appropriate post-hoc tests).

MEDC 8444 - FTE: Doctoral

(1 cr; Prereq-Doctoral student, adviser and DGS consent; No Grade Associated; offered Every Fall, Spring & Summer; 6 academic progress units; 6 financial aid progress units)

(No description)

MEDC 8461 - Design of Cancer Therapeutics

(3 cr; A-F only; offered Spring Even Year)

Cancer Drug Therapy is a relatively new field of medicine that has undergone many medical and societal changes over the course of the last 100 years and in particular the last 60 years. The emphasis in this course will be to familiarize the student with the basic concepts of cancer biology and to survey current advanced approaches for the development and design of small molecule, protein and cell based therapeutics for the treatment of cancer.

MEDC 8471 - High Throughput Drug Discovery

(3 cr; Prereq-Undergraduate [chemistry or biochemistry] or instr consent; A-F only; offered Spring Even Year)

Combinatorial chemistry, multi-compound based technologies, their use in screening bioassays to discover lead compounds. Solidphase synthesis, designing compound libraries, pharmacological assay design, data interpretation, biological target selection, compound lead optimization.

MEDC 8500 - Design of Chemotherapeutic Agents

(2 cr; Prereq-5600 or instr consent; A-F or Audit; offered Periodic Fall)

Modern aspects of designing chemotherapeutic agents. Strategies for enzyme inhibition and metabolic blocks in development of anticancer, antimicrobial, and antiviral agents.

MEDC 8600 - Chemical Aspects of Drug Metabolism and Bioactivation

(2 cr; Prereq-5600 or instr consent; A-F or Audit; offered Periodic Fall)

Equivalent courses: PHAR 6245 (inactive, ending 07-SEP-99), PHAR 6246H (inactive, starting 05-SEP-00, was PHAR 6246 until 05-SEP-00)

Chemical and enzymatic mechanisms of biotransformation and bioactivation of drugs and other xenobiotics. Reactivity and fate of bioactivated metabolites.

MEDC 8666 - Doctoral Pre-Thesis Credits

(1 cr [max 6]; Prereq-Doctoral student who has not passed prelim oral; no required consent for 1st/2nd registrations, up to 12 combined cr; dept consent for 3rd/4th registrations, up to 24 combined cr; doctoral student admitted before summer 2007 may register up to four times, up to 60 combined cr; No Grade Associated; offered Every Fall, Spring & Summer; may be repeated for 12 credits; may be repeated 2 times)

tbd

MEDC 8700 - Advanced Concepts in Drug Design

(2 cr; Prereq-5600 or instr consent; A-F or Audit; offered Periodic Spring)

Equivalent courses: PHAR 6246H (inactive, ending 05-SEP-00, was PHAR 6246 until 05-SEP-00), CHEM 8700 (inactive), PHAR 6247H (inactive, starting 07-SEP-99, was PHAR 6247 until 05-SEP-00)

Current approaches to rational design of drugs.

MEDC 8753 - Molecular Targets of Drug Discovery

(3 cr; Prereq-5710 or 8002 or CHEM 5412 or structural biochemistry or instr consent; A-F or Audit; offered Fall Even Year)

Structure of biological macromolecules that are targets of drugs. Techniques to accelerate directed drug discovery. Protein structure/interactions. Popular target classes. Computational tools for visualizing/analyzing protein-ligand and protein-protein interactions. Structural characterization at a level sufficient to underpin critical data evaluation. Biophysical techniques to assess weak ligand binding and suitable for fragment-based lead discovery.

MEDC 8760 - Design of Peptidomimetics

(2 cr; Prereq-5600 or instr consent; A-F or Audit; offered Periodic Fall)

Current approaches to design and synthesis of mimetics of biologically active peptides. Structural and conformational rationale used in peptidomimetic design.

MEDC 8777 - Thesis Credits: Master's

(1 cr [max 18]; Prereq-Max 18 cr per semester or summer; 10 cr total required [Plan A only]; No Grade Associated; offered Every Fall, Spring & Summer; may be repeated for 50 credits; may be repeated 10 times)

(No description)

MEDC 8800 - Medicinal Chemistry Laboratory Techniques

(1 cr [max 2]; Prereq-Grad med chem major or instr consent; S-N or Audit; offered Every Fall & Spring; may be repeated for 4 credits; may be repeated 4 times)

Experiential rotations in medicinal chemistry research laboratories.

MEDC 8888 - Thesis Credit: Doctoral

(1 cr [max 24]; Prereq-Max 18 cr per semester or summer; 24 cr required; No Grade Associated; offered Every Fall, Spring & Summer; may be repeated for 100 credits; may be repeated 10 times)

(No description)

MEDC 8900 - Directed Studies in Medicinal Chemistry

(1 cr [max 10]; Prereq-Grad med chem major or instr consent; A-F only; offered Every Fall & Spring; may be repeated for 10 credits; may be repeated 8 times)

Directed Studies in Medicinal Chemistry facilitates advisor directed study in a special topic for credit, affording students the opportunity to acquire a level of expertise in a specific specialty of laboratory work or scholarship beyond that which can obtained in other didactic coursework. It is required that all students obtaining a Plan B Master of Science in Medicinal Chemistry (Plan B MS) complete at least one project in Directed Studies. Other graduate students with an interest in Medicinal Chemistry research are also eligible to enroll. The course may be taken more than once, and even concurrently. If taken concurrently, different research advisors must guide each project. The course will be open for enrollment during all academic terms (Fall, Spring and Summer). Prior to enrollment, the student will work to identify a MedChem graduate faculty member to serve as project advisor, who will help the student outline project goals and expectations. A short outline of the project should be presented to the Course Director for approval prior to enrollment.

---

Please report problems with this form to the webmaster.

---

This software is free and available under the GNU GPL.
© 2000 and later T. W. Shield

Contact Information

Aerospace Engineering and Mechanics

107 Akerman Hall, 110 Union St. SE
Minneapolis, MN, 55455-0153

P: 612-625-8000 | F: 612-626-1558