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Comparative & Molecular Biosci (CMB) Courses

Academic Unit: Veterinary Biomedical Science

CMB 5200 - Statistical Genetics and Genomics

(4 cr; A-F or Audit; offered Fall Even Year)

Equivalent courses: was MVB 5200 until 06-SEP-05

Statistical issues in genomics. Gene detection, including statistical analysis/designs for linkage study and for mapping quantitative trait loci. Linkage analysis using pedigree data for codominant/dominant markers. Using radiation hybrid mapping and single cell typing. Design issues in linkage analysis, parentage testing, and marker polymorphism.

CMB 5201 - Vaccine development for viral infectious diseases

(1 cr; A-F only; offered Every Spring)

Vaccine is the most cost-effective tool to combat viral infectious diseases, as illustrated by the successful eradication or significant reduction of once-devastating viral diseases such as smallpox, polio, rabies, and measles. The rapid development of vaccines for SARS-CoV-2, the causative agent for the COVID-19 pandemic, has helped to bring the pandemic under control. However, the misinformation about vaccines circulating in social media causes the anti-vaccine movement that threatens our public health and erodes the trust in biomedical sciences. In this course, we will: - Review basic knowledge of viruses and our immune system- Present the history and basic principles of vaccines - Introduce the representative vaccines developed for major viral diseases such as smallpox, polio, influenza, hepatitis B, human papillomavirus (HPV), Ebola, and COVID-19 - Present the methods for vaccine development - Highlight the challenges and the innovative research in vaccine development - Discuss the benefits and risks of vaccines The overall goal of the course is to provide students with scientific knowledge of vaccines, foster students' interests in vaccine development, help students understand the basic concepts of virology and immunology, and prepare interested students for biomedical careers. Targeted students: graduate students, professional students, and senior undergraduate students who are interested in medical virology, immunology, and vaccines.

CMB 5300 - Prion Biology and Ecology

(2 cr; A-F or Audit; offered Every Spring)

Prions are among the most mysterious pathogens known to science. Few other disease agents have confounded physicians, biologists, and chemists to the extent that prions have. In this course, we will learn about the fundamental characteristics of infectious prions, including how they become infectious and the particular diseases they are associated with. The entire field of prion biology is young and, because of this, scientists are making exciting and important discoveries that add to our understanding of infectious proteins. To appreciate how the scientific community arrived at the current state of knowledge about prions, we will revisit and challenge some of the basic assumptions and orthodoxies of biology.

CMB 5303 - Comparative Models of Disease

(2 cr; A-F only; offered Every Spring)

Disease processes in organ systems. Examples of animal models. Comparative medicine. Clinical relevance of problem/disease. Animal models used to study disease process/problem. Lectures.

CMB 5340 - Structural Biology in Biomedical Research

(2 cr; A-F only; offered Every Spring)

Structural biology plays a central role in biomedical research, but it is a challenging field to learn. This course teaches basic structural biology and its applications to biomedical research in an accessible and practical fashion. We will cover the principles and procedures of structural biology as well as structural biology databases and software. Students will also learn how structural biology is used to solve scientific problems (e.g., elucidating molecular mechanisms and designing drugs and vaccines) and acquire skills that may facilitate their own research (e.g., reading structural biology literature and designing mutations). Student learning is achieved through classroom lectures, computer labs, written critique and oral presentation of research literature, and participation in discussion. The overall goal of this course is to help students understand structural biology and use it in their own research.

CMB 5571 - Pathogenomics and Molecular Epidemiology - Learning to Fly

(3 cr; A-F only; offered Every Spring)

This course is designed provide an introduction to the use of molecular methods in our understanding of the pathogenesis, etiology, and transmission of infectious diseases that are important to both animals and public health. This is intended as a hands-on course for the student to learn techniques related to genome sequencing, pangenome analysis, phylogenetic analysis, and metagenomic analysis, and then apply these techniques towards their own research.

CMB 5594 - Directed Research in Comparative and Molecular Biosciences (independent study)

(1 cr [max 4]; Prereq-Jr, instr consent; Student Option; offered Every Fall, Spring & Summer; may be repeated for 8 credits; may be repeated 8 times)

Equivalent courses: was MVB 5594 until 06-SEP-05

Independent study as determined by instructor. Usual activity includes conducting research in instructor's lab.

CMB 5910 - Grantwriting: What Makes a Winning Proposal?

(2 cr; Student Option; offered Every Spring)

Equivalent courses: VMED 5910

Components of a strong proposal. Grant submission process. What reviewers look for. How to locate grant announcements that match research interests.

CMB 5912 - Creativity

(1 cr; Student Option; offered Every Spring)

Creativity will be explored and used to provide new perspectives on a variety of professional goals, activities and challenges. Lectures will be followed by a mixture of individual and group activities to provide a guided exploration of how these creative approaches can be applied to many situations. Students will learn skills to expand their vision, become more adept at problem solving, design more innovative research, inspire themselves and others and become more fascinating communicators.

CMB 5915 - Essential Statistics for Life Sciences

(3 cr; A-F or Audit; offered Every Fall)

This course is a broad overview of the principles and methods of statistical analysis used in life sciences research, including biological, veterinary, and translational research, and provides the background a new researcher needs to understand and apply commonly used statistical methods and the preparation needed for more advanced coursework. Classes will include general instruction and background information, detailed examples of how to perform the analyses, with actual data sets, and discussion on how the topic has been applied in biological research, including reading and assessing papers in the field. Computing will be performed using the R software environment, though students may use alternate software with permission. Topics will include: ? Descriptive statistics and exploratory graphics ? Understanding statistical inference and interpreting P-values and confidence intervals. ? One and two sample inference, including t-tests, proportion tests, and non-parametric alternatives ? Linear regression, including the effects of confounders ? ANOVA methods, including pairwise comparisons and multiple comparisons

CMB 8012 - Basic Concepts in Skeletal Biology

(2 cr; Prereq-CMB grad student or instr consent; A-F only; offered Every Spring)

Cells (osteoblasts, osteoclasts, chrondrocytes) that make up skeleton. Transcription/signaling networks regulating cell growth/differentiation. Mechanisms of bone remodeling. Regulation of bone by agents such as hormones.

CMB 8100 - Research Rotation in Comparative and Molecular Biosciences

(1 cr; S-N only; offered Every Fall & Spring; may be repeated for 2 credits; may be repeated 2 times)

Equivalent courses: was MVB 8100 until 06-SEP-05

Current developments in faculty research. Topics specific to research adviser's area of interest. Eight weeks.

CMB 8134 - Ethical Conduct of Animal Research

(3 cr; Student Option; offered Every Fall)

Equivalent courses: was MVB 8134 until 06-SEP-05, VMED 8134, ANSC 8134

Ethical considerations in the use of animal subjects in agricultural, veterinary, and biomedical research. Federal, state, and University guidelines relating to proper conduct for acquisition and use of animals for laboratory, observational, epidemiological, and clinical research. Regulatory requirements. Bases for proper conduct. Societal impact on scientific investigations utilizing animal subjects.

CMB 8202 - Mechanisms of Animal Health and Disease II

(3 cr; A-F only; offered Every Fall)

Equivalent courses: was MVB 8202 until 06-SEP-05

Multi-perspective approach to critically evaluating journal articles, as done for peer-reviewed journals. Aspects of host/pathogen interactions, including molecular/genetic mechanisms of host resistance/pathogenesis.

CMB 8208 - Neuropsychopharmacology

(3 cr; Prereq-graduate student and instr consent; A-F or Audit; offered Fall Even Year)

Equivalent courses: PSY 8061

Relationships between drugs. Biochemical, behavioral, neurophysiological consequences. Functional biogenic amine, peptidergic, other pathways. Neuronal function/behavior. Feedback mechanisms, induction, inhibition. Stimulants, hallucinogens, depressants, opiates. Student presentations.

CMB 8303 - Comparative Models of Disease

(2 cr; Prereq-Enrollment in a biological sciences grad program or instr consent; A-F only; offered Every Spring)

Disease processes in organ systems. Examples of animal models. Comparative medicine. Clinical relevance of problem/disease. Animal models used to study disease process/problem. Lectures.

CMB 8333 - FTE: Master's

(1 cr; Prereq-Master's student, adviser and DGS consent; No Grade Associated; offered Every Fall, Spring & Summer; 6 academic progress units; 6 financial aid progress units)

Equivalent courses: was MVB 8333 until 06-SEP-05

(No description)

CMB 8344 - Mechanisms of Hormone Action

(2 cr; Prereq-Course in biochemistry or cell biology or instr consent; Student Option; offered Fall Even Year)

Mechanisms of hormone/cytokine action. Focuses on major signal transduction/apoptosis. Topics incorporate pharmacology, biochemistry, and cell biology of hormone action in relevant physiological systems. Lectures on basic principles. Specialized lectures. Discussion of primary literature.

CMB 8361 - Neuro-Immune Interactions

(3 cr; Prereq-[MICB 5218 or equiv], [NSC 5561 or equiv]; Student Option; offered Fall Odd Year)

Equivalent courses: was MVB 8361 until 06-SEP-05

Regulatory systems (neuroendocrine, cytokine, and autonomic nervous systems) linking brain and immune systems in brain-immune axis. Functional effects of bidirectional brain-immune regulation. Offered fall of odd-numbered years.

CMB 8371 - Mucosal Immunobiology

(3 cr; Prereq-MICa 8001 or equiv or instr consent; A-F or Audit; offered Periodic Fall)

Equivalent courses: was MVB 8371 until 06-SEP-05, MICA 8371, OBIO 8371

Host immune processes at body surfaces. Innate/adaptive immunity at mucosal surfaces. Interactions/responses of various mucosal tissues to pathogens. Approaches to target protective vaccination to mucosal tissues. Lectures, journal.

CMB 8394 - Research in Comparative Biomedical Sciences

(1 cr [max 6]; Prereq-Grad CMB major; Student Option; offered Every Fall, Spring & Summer; may be repeated for 18 credits; may be repeated 5 times)

Equivalent courses: was MVB 8394 until 06-SEP-05

Directed research determined by student's interests, in consultation with faculty mentor.

CMB 8444 - FTE: Doctoral

(1 cr; Prereq-Doctoral student, adviser and DGS consent; No Grade Associated; offered Every Fall, Spring & Summer; 6 academic progress units; 6 financial aid progress units)

Equivalent courses: was MVB 8444 until 06-SEP-05

(No description)

CMB 8481 - Advanced Neuropharmaceutics

(4 cr; Prereq-instr consent; A-F or Audit; offered Fall Even Year)

Equivalent courses: was MVB 8481 until 06-SEP-05, NSC 8481, PHM 8481

Delivery of compounds to central nervous system (CNS) to activate proteins in specific brain regions for therapeutic benefit. Pharmaceutical/pharmacological issues specific to direct drug delivery to CNS.

CMB 8550 - Comparative and Molecular Biosciences Seminar

(1 cr; Prereq-Biol sciences grad student; S-N or Audit; offered Every Fall & Spring; may be repeated for 8 credits; may be repeated 8 times)

Equivalent courses: was MVB 8550 until 06-SEP-05

Student/faculty presentations of their own research or a directed topic.

CMB 8560 - Research and Literature Reports

(1 cr; S-N or Audit; offered Every Fall & Spring; may be repeated for 2 credits; may be repeated 2 times)

Equivalent courses: was MVB 8560 until 06-SEP-05

Current developments in cellular and molecular mechanisms of animal health and disease.

CMB 8571 - Pathogenomics and Molecular Epidemiology - Learning to Fly

(3 cr; A-F or Audit; offered Every Spring)

This course is designed provide an introduction to the use of molecular methods in our understanding of the pathogenesis, etiology, and transmission of infectious diseases that are important to both animals and public health. This is intended as a hands-on course for the student to learn techniques related to genome sequencing, pangenome analysis, phylogenetic analysis, and metagenomic analysis, and then apply these techniques towards their own research.

CMB 8777 - Thesis Credits: Master's

(1 cr [max 18]; Prereq-Max 18 cr per semester or summer; 10 cr total required [Plan A only]; No Grade Associated; offered Every Fall, Spring & Summer; may be repeated for 50 credits; may be repeated 10 times)

Equivalent courses: was MVB 8777 until 06-SEP-05

(No description)

CMB 8888 - Thesis Credit: Doctoral

(1 cr [max 24]; Prereq-Max 18 cr per semester or summer; 24 cr required; No Grade Associated; offered Every Fall, Spring & Summer; may be repeated for 100 credits; may be repeated 10 times)

Equivalent courses: was MVB 8888 until 06-SEP-05

(No description)

CMB 8910 - Statistical Principles of Research Design

(3 cr; Prereq-intro grad level stats course or it's equivalent; A-F or Audit; offered Every Spring)

This course is a broad overview of the principles and techniques of research design and methods used in veterinary and translational research, and provides the background a new researcher needs to understand the literature and make good decisions about what is appropriate for their research.

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